Beilstein J. Org. Chem.2017,13, 2883–2887, doi:10.3762/bjoc.13.280
substituents is of interest. Here we describe optimisation efforts in the synthesis of anti-2,3-difluorobutane-1,4-diol, as well as the synthesis of the corresponding syn-diastereomer. Both targets were synthesised using an epoxide opening strategy.
Keywords: acetalisomerization; deoxyfluorination; epoxide
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Graphical Abstract
Scheme 1:
The synthesis of anti-2,3-difluorobutan-1,4-diol (anti-5) [17].